KMID : 0939920210530020445
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´ëÇѾÏÇÐȸÁö 2021 Volume.53 No. 2 p.445 ~ p.456
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Associations of Serum Lipid Level with Gastric Cancer Risk, Pathology, and Prognosis
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Pih Gyu-Young
Gong Eun-Jeong Choi Ji-Young Kim Min-Ju Ahn Ji-Yong Choe Jae-Won Bae Suh-Eun Chang Hye-Sook Na Hee-Kyong Lee Jeong-Hoon Jung Kee-Wook Kim Do-Hoon Choi Kee-Don Song Ho-June Lee Gin-Hyug Jung Hwoon-Yong
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Abstract
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Purpose: The association of serum lipids with gastric cancer is controversial. We clarified the role of serum lipids in the development, progression, and prognosis of gastric cancer.
Materials and Methods: In total, 412 patients diagnosed with gastric cancer were prospectively recruited, and 2,934 control subjects who underwent screening endoscopy were enrolled from December 2013 to March 2017 to conduct a case-control study in a tertiary center. Serum lipid profiles, including total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), apolipoprotein A-I (apoA-I), and apolipoprotein B, and clinicopathologic characteristics were analyzed.
Results: The gastric cancer group showed significantly lower HDL-C, higher LDL-C, and lower apoA-I level than the control group. In multivariate analysis, old age (odds ratio [OR], 1.051; p < 0.001), smoking (OR, 1.337; p < 0.001), a family history of gastric cancer (OR, 2.038; p < 0.001), Helicobacter pylori seropositivity (OR, 4.240; p < 0.001), lower HDL-C (OR, 0.712; p=0.020), and higher LDL-C (p=0.002) were significant risk factors for gastric cancer. Lower HDL-C and higher LDL-C remained significant after adjustments for covariates, including age and sex. In a subgroup analysis of the gastric cancer group, lower TG levels were associated with undifferentiated histology. No serum lipids were associated with overall survival.
Conclusion: Lower HDL-C and higher LDL-C were associated with the risk of gastric cancer, even after adjusting for age, sex, and other factors. In the gastric cancer group, undifferentiated histology was associated with lower TG levels.
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KEYWORD
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Stomach neoplasms, Dyslipidemias, Incidence, Prognosis
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